Garner Lab In the Department of Psychiatry

Investigating Mechanisms of Synaptic Plasticity and Neurodevelopmental Disabilities

Craig Garner is a professor in the Department of Psychiatry and Behavioral Sciences and the co-director of the Center for Research and Treatment of Down Syndrome at Stanford University. Dr. Garner is developmental neurobiologist interested in the molecular and cellular mechanisms underlying the formation, stability and plasticity of vertebrate synapses. He is investigating not only the role of individual proteins in the functional assembly of synapses, but also how environmental and genetic insults to the developing nervous system impairs cognitive function in neurodevelopmental disorders such as Down syndrome, autism and fragile X syndrome.

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Innovations in Down Syndrome: Unlocking Great Potential

Studies of synapse function in a mouse model of Down syndrome have led to new discoveries about memory and learning. A simple drug treatment improved memory in these mice. Now there is hope that a similar therapy will benefit individuals with Down syndrome. Together with colleagues at the Stanford School of Medicine, Dr. Garner is working to design and implement a clinical trial to study the safety and efficacy of this treatment in children and adults with Down syndrome. We are committed to working closely with the Down syndrome community to plan and fundraise in support of these efforts.

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