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Reference: Zhai et al., Neuron 29:131-143 (2001) 
Dense core vesicles are present in axons and cell soma of 3 div hippocampal neurons. EM micrographs of hippocampal neurons cultured for 3 div. 80 nm dense core vesicles are observed along microtubules (MT) in axons (arrows). Clear center vesicles were also present (small arrow). A coated vesicle can be observed invaginating from the plasma membrane (asterisk). An electron dense region most likely represent a nascent synapse (arrowheads) can be observed between axon and adjacent cell soma.. Scale bars, 100 nm in all panels.
Fig. 8. In Axonal Growth Cones, Piccolo Colocalizes with the Components of Active Zone but Not SVs(A–O) Neurons cultured for 4 days in vitro were double labeled for Piccolo (A, D, G, J, and M) in green and Bassoon (B), synaptotagmin (E), VAMP2/synaptobrevin2 (H), N-cadherin (K), or chromogranin B (N) in red. The distal portions of axons and their growth cones were displayed in a vertical orientation with their growth cones at the top. A high degree of colocalization can be observed between Piccolo and Bassoon (C), but almost no colocalization can be observed between Piccolo and synaptotagmin (F) or between Piccolo and VAMP2 (I). Piccolo partially colocalized with N-cadherin (L) and with chromogranin B (O). Scale bars, 10 μm in all panels.
